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In the options dialog, go to the "Display" tab, there you can change the crosshair colors. Make note that the crosshairs of different "spaces" and space orientations can be colored separatedly from one another in the "Context" area. Select all of the contexts that offer crosshairs as an "Interface Element", and change each one as you wish. Also note the "Tint for X, Y, Z" option, it better to turn it off for 2D work.